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GEMS Research Topics : Vascular Biologyde Lanerolle, PrimalPhD, University of California, San Diego Research Interests Research Description The cytoskeleton in signal transduction; Molecular motors in the nucleus
Du, XiaopingM.D., Ph.D., University of Sydney, Australia Research Interests Research Description Thrombosis, hemostasis, and vascular biology; molecular mechanisms and molecular pharmacology of platelet and endothelial cell functions.
Fukai, TohruMD, PhD, Kyushu University, Fukuoka, Japan Research Interests Research Description To determine the role of oxidative stress and copper transport system in cardiovascular disease.
Lam, StephenPhD, University of Toronto Research Interests Research Description Platelet adhesive functions in hemostasis and thrombosis; structure- function relationship of integrin alpha IIb?3.
Le Breton, GuyPh.D., University of Chicago Research Interests Research Description Fundamental mechanisms and signal transduction processes involved in platelet activation and inhibition.
Malik, A.B.Ph.D., University of Toronto, Canada Research Interests Research Description Gene regulation in endothelial cells; expression of adhesion molecules and their transcriptional regulation; regulation of endothelial transport; assembly of adherens junctions; function of caveolin-1 in endothelial cells.
Mehta, DollyPh.D., Delhi University, India Research Interests Research Description Rho regulation of actin polymerization.
Minshall, RichardPh.D., University of Illinois at Chicago Research Interests Research Description Investigates signaling mechanisms regulating paracellular and transcellular permeability of the endothelium to macromolecules and therapeutic agents. Confocal microscopy, physiological, molecular, cellular, and biochemical approaches are used to study trafficking of caveolae, organization and remodeling of the cytoskeleton and cell-cell junctions, protein and fluid permeability, and signaling modules that regulate endothelial cell function. Current projects focus on 1) the signaling molecules that regulate caveolae-mediated endocytosis and transcytosis, 2) delivery of therapeutic agents across the vascular barrier, and 3) the role of caveolae in inflammation-induced increase in permeability.
Skidgel, RandalPh.D., University of California, San Diego Research Interests Research Description Role of peptidases in the regulation of peptide hormone receptor signaling and the regulation of nitric oxide synthase activity in vascular disease.
Snapp, KarenD.D.S., Ph.D., University of Iowa Research Interests Research Description Leukocyte adhesion and migration; interactions mediated by the selectin family of adhesion molecules.
Tiruppathi, ChinnaswamyPh.D., University of Madras Research Interests Research Description Our primary research interest is to study the molecular mechanism that regulates vascular inflammation. Pro- inflammatory mediator thrombin induces vascular inflammation by cleaving the endothelial cell surface protease activated receptor-1 (PAR-1). PAR-1 activation causes vascular leakage and neutrophil adhesion-mediated vascular injury. Ca2+ signaling plays an important role in the mechanism of thrombin-induced vascular injury. Currently, we are investigating how thrombin increases intracellular Ca2+ by opening plasma membrane transient receptor potential channels expressed in endothelial cells. In addition, we are also investigating the role of Ca2+ signaling in the mechanism of nuclear factor ?B (NF-?B) activation- dependent expression of inflammatory genes in endothelial cells.
Ushio-Fukai, MasukoPhD, Kyushu University, Fukuoka, Japan Research Interests Research Description To determine the role of reactive oxygen species in angiogenesis and cardiovascular diseases using cell culture, live cell imaging, cell fractionation, molecular and cell biological analysis as well as in vivo models with knockout and transgenic mice.
Voyno-Yasenetskaya, TatyanaM.D., Ph.D., Institute of Pathophysiology, Moscow Research Interests Research Description G-protein regulatory mechanisms and control of cellular proliferation and cytoskeleton.
Wary, Kishore K.PhD, North Eastern Hill University, India Research Interests Research Description Biology of endothelial cells; cell- cell and cell-matrix interactions in endothelial cells; integrin, beta- catenin, VE-cadherin and Wnt mediated signaling in endothelial cells; adult stem cells; wound healing; angiogenesis and tumor progression.
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