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GEMS Research Topics : Signal Transduction and Cell SignalingAlexander, KennethPh.D., University of Washington Research Interests Research Description Use of behavioral and electrophysiological tests to define the relationship between vision impairment and the pathophysiology of ocular diseases.
de Lanerolle, PrimalPhD, University of California, San Diego Research Interests Research Description The cytoskeleton in signal transduction; Molecular motors in the nucleus
de Tombe, PieterPh.D. University of Calgary, Canada Research Interests Research Description Our research program is focused on unraveling molecular mechanisms underlying contractile protein function and regulation in health and disease. Our studies are both integrative and molecular in nature, spanning from control of cardiac pump function in the intact organism, to protein structure-function relationships as determined at the level of a few sarcomeres using sophisticated biophysical techniques. Our long term goals are to gain full understanding of the chemo-mechanical transduction processes underlying muscle contraction, and to use this knowledge to provide for a basic scientific rational to guide development of future novel treatment strategies aimed to combat cardiac disease in man.
Du, XiaopingM.D., Ph.D., University of Sydney, Australia Research Interests Research Description Thrombosis, hemostasis, and vascular biology; molecular mechanisms and molecular pharmacology of platelet and endothelial cell functions.
Fall, ChrisPh.D., University of Virginia Research Interests Research Description Computational and experimental approaches for understanding the neuromodulation of cortical activity patterns; computational and experimental cell biology of intracellular Ca2+ signaling and related second messengers; mechanisms of cell death in neurodegenerative disease.
Federle, MichaelPh.D., Emory University Research Interests Research Description Cell-cell signaling in bacteria, a process termed Quorum Sensing. We are identifying the chemical signals and signaling pathways used by bacteria to control population-wide behaviors, which include their ability to cause disease in humans. Eventually we hope to discover means by which we can interfere with bacteria's communication processes and ultimately alter the progression of bacterial infections.
García-Martínez, JesúsM.D., Ph.D., CINVESTAV, México Research Interests Research Description Signal transduction in striated muscle. Excitation-contraction coupling and gene expression in skeletal and cardiac muscle.
Gibori, GeulaPhD, Tel Aviv University Research Interests Research Description
Goldspink, PaulPh.D., University of Illinois at Chicago Research Interests Research Description Molecular aspects of cardiac disease and injury. Growth and repair mechanisms through local growth factor regulation, in particular IGF-1.
Jaffe, RandalPhD, University of California at Davis Research Interests Research Description Mechanism of hormonal regulation of female reproductive genes.
Kozasa, TohruMD/PhD, University of Tokyo, Japan Research Interests Research Description G-protein-mediated signal transduction pathways; Function of RGS proteins. Mechanism of regulation of Rho family GTPases (Rho, Rac, Cdc42) by G protein- coupled receptors.
Lau, LesterPh.D., Cornell University Research Interests Research Description Tumor Angiogenesis, Cardiovascular Development, Extracellular Matrix Signaling, Aging
Le Breton, GuyPh.D., University of Chicago Research Interests Research Description Fundamental mechanisms and signal transduction processes involved in platelet activation and inhibition.
Malik, A.B.Ph.D., University of Toronto, Canada Research Interests Research Description Gene regulation in endothelial cells; expression of adhesion molecules and their transcriptional regulation; regulation of endothelial transport; assembly of adherens junctions; function of caveolin-1 in endothelial cells.
Matsumura, PhilipPh.D., Rochester University Research Interests Research Description Mechanisms of signal transduction in bacterial chemotaxis. By combining genetics with biochemistry and structural chemistry, we are defining the detailed protein-protein interactions that constitute the biochemical pathway of signal transduction.
Mehta, DollyPh.D., Delhi University, India Research Interests Research Description Rho regulation of actin polymerization.
Minshall, RichardPh.D., University of Illinois at Chicago Research Interests Research Description Investigates signaling mechanisms regulating paracellular and transcellular permeability of the endothelium to macromolecules and therapeutic agents. Confocal microscopy, physiological, molecular, cellular, and biochemical approaches are used to study trafficking of caveolae, organization and remodeling of the cytoskeleton and cell-cell junctions, protein and fluid permeability, and signaling modules that regulate endothelial cell function. Current projects focus on 1) the signaling molecules that regulate caveolae-mediated endocytosis and transcytosis, 2) delivery of therapeutic agents across the vascular barrier, and 3) the role of caveolae in inflammation-induced increase in permeability.
Nakamura, ToruPh.D, University of Colorado, Boulder Research Interests Research Description Roles of Checkpoint Proteins and Chromatin Modifications in Genome Stability, DNA repair and Telomere Maintenance
Nonn, LarisaPhD, University of Arizona Research Interests Research Description Prostate cancer prevention by dietary agents (vitamin D, soy, lycopene) Primary human prostatic cell cultures as a model system The role of microRNAs and prostate cancer prevention. mRNA and microRNA expression profiling from archival tissue specimens
O'Bryan, John P.Ph.D., University of North Carolina at Chapel Hill Research Interests Research Description The research in the lab is focused on the role of scaffolding proteins in the regulation of signal transduction pathways, protein ubiquitylation, trafficking and endocytosis.
Pandey, SubhashPh.D., Central Drug Research Institute Research Interests Research Description Molecular and cellular neurobiology of alcohol and drug addiction.
Popov, SergeyPh.D., Moscow State University Research Interests Research Description
Qian, HaohuaPh.D. Research Interests Research Description Cellular and molecular basis of signal processing in the retina.
Rasenick, MarkPh.D., Wesleyan University Research Interests Research Description G protein signaling and the cytoskeleton; regulation of synaptic shape by neurostranmitters; molecular biology of depression
Russell, BrendaPhD, University London, UK Research Interests Research Description Dr. Russell's scientific training, background, experience, and productivity encompass a range of disciplines and forge linkages in the continuum between quantitative biology, bioengineering and physiology. Her current NIH support funds two collaborative projects, one on heart failure for regulation of protein synthesis and remodeling of cell shape, and the other on development of a novel cell culture system using bioengineering and surface chemistry modification. Many of her studies have been done in close collaboration with clinicians (muscular dystrophies, urinary incontinence, heart failure).
Skidgel, RandalPh.D., University of California, San Diego Research Interests Research Description Role of peptidases in the regulation of peptide hormone receptor signaling and the regulation of nitric oxide synthase activity in vascular disease.
Snapp, KarenD.D.S., Ph.D., University of Iowa Research Interests Research Description Leukocyte adhesion and migration; interactions mediated by the selectin family of adhesion molecules.
Solaro, R. JohnPh.D., University of Pittsburgh Research Interests Research Description Integrated Molecular, Structural, and Cellular Biology of Heart Muscle Physiology, Pathology, and Pharmacology
Tyner, AngelaPh.D. University of Chicago Research Interests Research Description Regulation of epithelial cell differentiation; Cell cycle regulation in regenerating tissues; Cancer
Ucker, DavidPh.D., University of California, San Francisco Research Interests Research Description Mechanism and regulation of the processes of physiological cell death and the innate immune recognition and non-inflammatory clearance of cell corpses.
Ushio-Fukai, MasukoPhD, Kyushu University, Fukuoka, Japan Research Interests Research Description To determine the role of reactive oxygen species in angiogenesis and cardiovascular diseases using cell culture, live cell imaging, cell fractionation, molecular and cell biological analysis as well as in vivo models with knockout and transgenic mice.
Voyno-Yasenetskaya, TatyanaM.D., Ph.D., Institute of Pathophysiology, Moscow Research Interests Research Description G-protein regulatory mechanisms and control of cellular proliferation and cytoskeleton.
Wary, Kishore K.PhD, North Eastern Hill University, India Research Interests Research Description Biology of endothelial cells; cell- cell and cell-matrix interactions in endothelial cells; integrin, beta- catenin, VE-cadherin and Wnt mediated signaling in endothelial cells; adult stem cells; wound healing; angiogenesis and tumor progression.
Wolska, BeataPh.D., Postgraduate Center of Medical Education, Warsaw, Poland Research Interests Research Description Role of calcium and myofilaments in controlling cardiac function.
Zhao, You-YangPhD Research Interests Research Description
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