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GEMS Research Topics : Molecular and Integrated Cardiac Biologyde Tombe, PieterPh.D. University of Calgary, Canada Research Interests Research Description Our research program is focused on unraveling molecular mechanisms underlying contractile protein function and regulation in health and disease. Our studies are both integrative and molecular in nature, spanning from control of cardiac pump function in the intact organism, to protein structure-function relationships as determined at the level of a few sarcomeres using sophisticated biophysical techniques. Our long term goals are to gain full understanding of the chemo-mechanical transduction processes underlying muscle contraction, and to use this knowledge to provide for a basic scientific rational to guide development of future novel treatment strategies aimed to combat cardiac disease in man.
García-Martínez, JesúsM.D., Ph.D., CINVESTAV, México Research Interests Research Description Signal transduction in striated muscle. Excitation-contraction coupling and gene expression in skeletal and cardiac muscle.
Goldspink, PaulPh.D., University of Illinois at Chicago Research Interests Research Description Molecular aspects of cardiac disease and injury. Growth and repair mechanisms through local growth factor regulation, in particular IGF-1.
Russell, BrendaPhD, University London, UK Research Interests Research Description Dr. Russell's scientific training, background, experience, and productivity encompass a range of disciplines and forge linkages in the continuum between quantitative biology, bioengineering and physiology. Her current NIH support funds two collaborative projects, one on heart failure for regulation of protein synthesis and remodeling of cell shape, and the other on development of a novel cell culture system using bioengineering and surface chemistry modification. Many of her studies have been done in close collaboration with clinicians (muscular dystrophies, urinary incontinence, heart failure).
Solaro, R. JohnPh.D., University of Pittsburgh Research Interests Research Description Integrated Molecular, Structural, and Cellular Biology of Heart Muscle Physiology, Pathology, and Pharmacology
Wolska, BeataPh.D., Postgraduate Center of Medical Education, Warsaw, Poland Research Interests Research Description Role of calcium and myofilaments in controlling cardiac function.
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