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GEMS Research Topics : Molecular Biophysics and Structural BiologyBouvier, MarlenePh.D., McGill University Research Interests Research Description An area of our research is focused on studying the class I antigen presentation pathway. The cell-surface presentation of antigens by class I MHC molecules is the culmination of an elaborated process that takes place in the endoplasmic reticulum (ER) and involves proteins such as tapasin, calreticulin, ERp57, and the transported associated with antigen processing. The characterization of these proteins and their functions is essential for elucidating the mechanistic basis of antigen selection in the ER. Another area of our research is to study the molecular basis of viral immune evasion mechanisms that operate by interfering with the class I antigen presentation pathway.
Caffrey, MichaelPh.D., University of Arizona Research Interests Research Description Determinants of viral and toxin entry
de Tombe, PieterPh.D. University of Calgary, Canada Research Interests Research Description Our research program is focused on unraveling molecular mechanisms underlying contractile protein function and regulation in health and disease. Our studies are both integrative and molecular in nature, spanning from control of cardiac pump function in the intact organism, to protein structure-function relationships as determined at the level of a few sarcomeres using sophisticated biophysical techniques. Our long term goals are to gain full understanding of the chemo-mechanical transduction processes underlying muscle contraction, and to use this knowledge to provide for a basic scientific rational to guide development of future novel treatment strategies aimed to combat cardiac disease in man.
Gettins, PeterD. Phil., Oxford University Research Interests Research Description Structure and function of serpin superfamily; ligand recognition by receptors of the LDL receptor family; protein NMR spectroscopy; X-ray crystallography
Kaplan, JackPhD, London University Research Interests Research Description Molecular characterization of P-type ATPases (Ion Pumps): structure- function relations, synthesis, assembly and trafficking. Mechanisms and Regulation of Copper transport in Human Cells.
Lavie, ArnonPh.D., Brandeis University Research Interests Research Description Structure-based design of novel therapeutic agents by prodrug development and enzyme modifications. X-ray crystallographic structure determination of enzymes involved in prodrug activation.
Solaro, R. JohnPh.D., University of Pittsburgh Research Interests Research Description Integrated Molecular, Structural, and Cellular Biology of Heart Muscle Physiology, Pathology, and Pharmacology
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