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GEMS Research Topics : ImmunologyBouvier, MarlenePh.D., McGill University Research Interests Research Description An area of our research is focused on studying the class I antigen presentation pathway. The cell-surface presentation of antigens by class I MHC molecules is the culmination of an elaborated process that takes place in the endoplasmic reticulum (ER) and involves proteins such as tapasin, calreticulin, ERp57, and the transported associated with antigen processing. The characterization of these proteins and their functions is essential for elucidating the mechanistic basis of antigen selection in the ER. Another area of our research is to study the molecular basis of viral immune evasion mechanisms that operate by interfering with the class I antigen presentation pathway.
Chan, LawrenceM.D., University of Pennsylvania Research Interests Research Description Molecular Mechanism of Chronic Skin Inflammation, Atopic Dermatitis.
Chen, ZhengM.D., Ph.D., Peking Union Medical College Research Interests Research Description Fundamental immunology of antigen- specific gamma delta T cells; gamma delta T cell-based immunotherapeutics; MHC class I-restricted CD8+ CTL responses in TB and AIDS; Vaccine development for TB and AIDS; Immunopathogenesis in AIDS virus- mycobacterial coinfection; T cell- targeted biodefense.
Cohen, EdwardM.D., Washington University Research Interests Research Description DNA based vaccines for cancer therapy.
Kalyanasundaram, RamaswamyPhD, University of Calgary Research Interests Research Description Molecular basis of host evasion by pathogens; identify novel antigens for vaccine or drug development
Kenter, AmyPhD, Yeshiva (Albert Einstein College of Medicine) Research Interests Research Description Genetic mechanisms of immunoglobulin gene recombination; DNA-binding proteins; B cell specific nucleic enzymes; plasmid recombination assays.
Li, JianxunPh.D., City University of New York Research Interests Research Description Molecular Mechanism of Immune Cell Activation.
Marucha, PhillipPhD, University of Connecticut Research Interests Research Description Stress-Impaired Oxygen Dependent Transcription in Wounds; Distress, Saliva Composition, and Saliva Functions; Interdisciplinary Research in Cancer from an Oral Perspective; Modulation of Inflammation by Stress and Social Factors; Mechanisms of Neuroendocrine Regulation of Wound Healing During Aging
Mokyr, MargalitPh.D., Rush University Research Interests Research Description Molecular mechanism of immunopotentiation by anticancer drugs
Prabhakar, BellurPh.D., Johns Hopkins University Research Interests Research Description Role of regulatory T cells in autoimmunity, Molecular mechanisms of actions of IG20 splice variants that can promote either apoptosis or cell- growth. Therapeutic interventions against SARS.
Ucker, DavidPh.D., University of California, San Francisco Research Interests Research Description Mechanism and regulation of the processes of physiological cell death and the innate immune recognition and non-inflammatory clearance of cell corpses.
Ye, RichardM.D., Ph.D., Washington University Research Interests Research Description Signaling through G-protein-coupled receptors; molecular mechanisms of leukocyte activation.
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