Graduate Education in Medical Sciences at University of Chicago





GEMS Research Topics : Gene Regulation

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Ackerman, Steven

Ph.D., McGill University
Professor of Biochemistry and Molecular Genetics
sackerma@uic.edu   312-996-6149

Research Interests
Gene Regulation, Lung Biology, Development

Research Description

Transcriptional mechanisms that regulate blood cell (granulocyte/eosinophil) lineage-specific development and gene expression during hematopoiesis. Cellular, molecular and immunobiology of the eosinophil granulocyte, focusing on pro-inflammatory effector functions in the pathogenesis of asthma and other allergic diseases such as eosinophilic esophagitis - mechanisms of eosinophil-mediated tissue damage, repair-remodeling and fibrosis are being investigated.

 

de Lanerolle, Primal

PhD, University of California, San Diego
Professor of Physiology and Biophysics and Medicine
Prima@UIC.edu   312-996-6430

Research Interests
Signal Transduction and Cell Signaling, Gene Regulation, Vascular Biology

Research Description

The cytoskeleton in signal transduction; Molecular motors in the nucleus

 

Diekwisch, Thomas

DDS, Ph.D. (sci), Ph.D. (phil), Philipps-University of Marburg, West Germany
Professor of Oral Biology and Adjunct Professor of Anatomy and Cell Biology
tomdkw@uic.edu   312-413-9683

Research Interests
Gene Regulation, Development,

Research Description

Developmental, molecular, and evolutionary biology of tooth enamel and periodontium

 

Frolov, Maxim

Ph.D, Moscow State University
Assistant Professor of Biochemistry and Molecular Genetics
mfrolov@uic.edu   312-413-5797

Research Interests
Cell Cycle and Apoptosis, Gene Regulation, Genetics

Research Description

The role of E2F and pRB in normal and oncogenic proliferation. The function of the novel Hippo tumor suppressor pathway in Drosophila.

 

Fukai, Tohru

MD, PhD, Kyushu University, Fukuoka, Japan
Associate Professor of Medicine, Section of Cardiology, and Pharmacology
tfukai@uic.edu   312-996-6730

Research Interests
Gene Regulation, Molecular Biology, Vascular Biology

Research Description

To determine the role of oxidative stress and copper transport system in cardiovascular disease.

 

Gartel, Andrei

Ph.D., Institute of Virology, Moscow, Russia
Assistant Professor, Molecular Genetics, Microbiology and Immunology
agartel@uic.edu   312-996-1855

Research Interests
Cancer Biology, Cell Cycle & Apoptosis Gene Regulation, Gene Regulation

Research Description

Regulation of CDK inhibitor p21 in normal and cancer cells, Anticancer drugs that target antiapoptotic pathways

 

Ikegaki, Naohiko

PhD, University of Pennsylvania
Visiting Associate Professor of Anatomy and Cell Biology
ikegaki@uic.edu   

Research Interests
Cancer Biology, Gene Regulation, Neuroscience

Research Description

Biology and therapeutic approaches of neuroblastoma; functions of MYCN, EPH receptors, and ephrims in neuroblastoma

 

Kennedy, John

PhD, Medical College of Virginia
Associate Professor of Physiology and Biophysics
Jkennedy@uic.edu   312-996-7992

Research Interests
Gene Regulation, Cardiovascuar Biology, Metabolism/Biochemistry

Research Description

Molecular Mechanisms controlling expression of metabolic genes during cardiac and skeletal muscle adaptation.

 

Kenney, Linda

PhD, University of Pennsylvania
Professor Microbiology and Immunology
kenneyl@uic.edu   312-413-0576

Research Interests
Gene Regulation, Biochemistry, Microbiology

Research Description

Two-component signal transduction; Regulation of Salmonella pathogenicity Island 2 gene expression; Regulation of outer membrane proteins by EnvZ/OmpR

 

Kenter, Amy

PhD, Yeshiva (Albert Einstein College of Medicine)
Associate Professor Microbiology and Immunology
star1@uic.edu   312-995-5293

Research Interests
Immunology, Gene regulation,

Research Description

Genetic mechanisms of immunoglobulin gene recombination; DNA-binding proteins; B cell specific nucleic enzymes; plasmid recombination assays.

 

Matsumura, Philip

Ph.D., Rochester University
Professor, Microbiology and Immunology
Philip.Matsumura@uic   312-996-2286

Research Interests
Microbiology, Signal Transduction and Cell Signaling, Gene regulation

Research Description

Mechanisms of signal transduction in bacterial chemotaxis. By combining genetics with biochemistry and structural chemistry, we are defining the detailed protein-protein interactions that constitute the biochemical pathway of signal transduction.

 

McLachlan, Alan

Ph.D., University of Aberdeen, Scotland
Professor, Medicine, Microbiology and Immunology
mclach@uic.edu   312-355-0211

Research Interests
Virology, Gene Regulation, Host-Pathogen Biology

Research Description

Regulation of hepatitis B virus transcription and replication

 

Mirkin, Sergei

Ph.D., Institute of Molecular Genetics, Russian Academy of Sciences
Professor of Biochemistry and Molecular Genetics
mirkin@uic.edu   312-996-9610

Research Interests
Gene Regulation, Biochemistry, Genetics

Research Description

Genome Structure and Functioning; Molecular Mechanisms of Genetic Processes; Structure and Stability of DNA

 

Mokyr, Margalit

Ph.D., Rush University
Professor of Biochemistry and Molecular Genetics
mokyr@uic.edu   312-996-2343

Research Interests
Immunology, Cancer Biology, Gene regulation

Research Description

Molecular mechanism of immunopotentiation by anticancer drugs

 

Raychaudhuri, Pradip

Ph.D., Albert Einstein College of Medicine
Professor of Biochemistry and Molecular Gentics
pradip@uic.edu   312-413-0255

Research Interests
Cancer Biology, Cell cycle & Apoptosis, Gene Regulation

Research Description

We use both mammalian and yeast genetics to study DNA damage response, cell cycle checkpoints and tumor suppression

 

Walden, William

Ph.D., Washington University
Professor, Microbiology and Immunology
wwalden@uic.edu   312-996-8576

Research Interests
Biochemistry, Gene Regulation,

Research Description

Mechanisms of iron regulation and FeS cluster assembly; translational mechanisms and regulation.

 

Yue, Beatrice

Ph.D.
Professor, Ophthamology and Visual Sciences
beatyue@uic.edu   996-6125

Research Interests
Gene Regulation, Vision Science,

Research Description

Biochemical and molecular basis of keratoconus; studies of glaucoma genes.