 |
GEMS Research Topics : BiochemistryBouvier, MarlenePh.D., McGill University Research Interests Research Description An area of our research is focused on studying the class I antigen presentation pathway. The cell-surface presentation of antigens by class I MHC molecules is the culmination of an elaborated process that takes place in the endoplasmic reticulum (ER) and involves proteins such as tapasin, calreticulin, ERp57, and the transported associated with antigen processing. The characterization of these proteins and their functions is essential for elucidating the mechanistic basis of antigen selection in the ER. Another area of our research is to study the molecular basis of viral immune evasion mechanisms that operate by interfering with the class I antigen presentation pathway.
Caffrey, MichaelPh.D., University of Arizona Research Interests Research Description Determinants of viral and toxin entry
Colley, KarenPh.D., Washington University Research Interests Research Description Control of glycoprotein biosynthesis during development and disease; mechanisms of Golgi protein trafficking and localization.
Kaplan, JackPhD, London University Research Interests Research Description Molecular characterization of P-type ATPases (Ion Pumps): structure- function relations, synthesis, assembly and trafficking. Mechanisms and Regulation of Copper transport in Human Cells.
Kenney, LindaPhD, University of Pennsylvania Research Interests Research Description Two-component signal transduction; Regulation of Salmonella pathogenicity Island 2 gene expression; Regulation of outer membrane proteins by EnvZ/OmpR
Lam, StephenPhD, University of Toronto Research Interests Research Description Platelet adhesive functions in hemostasis and thrombosis; structure- function relationship of integrin alpha IIb?3.
Lavie, ArnonPh.D., Brandeis University Research Interests Research Description Structure-based design of novel therapeutic agents by prodrug development and enzyme modifications. X-ray crystallographic structure determination of enzymes involved in prodrug activation.
Lazarov, OrlyPh.D., Weizmann Institute of Science Research Interests Research Description Cellular and molecular mechanisms underlying Alzheimer's disease; Misregulation of neurogenic processes in the AD brain; Neurogenesis and stem cell-based therapeutic approaches.
Mirkin, SergeiPh.D., Institute of Molecular Genetics, Russian Academy of Sciences Research Interests Research Description Genome Structure and Functioning; Molecular Mechanisms of Genetic Processes; Structure and Stability of DNA
Rong, LijunPh.D., Purdue University Research Interests Research Description Entry mechanisms of emerging viruses such as Ebola and SARS
Volz, KarlPh.D., University of California, San Diego Research Interests Research Description Protein structure and function
Walden, WilliamPh.D., Washington University Research Interests Research Description Mechanisms of iron regulation and FeS cluster assembly; translational mechanisms and regulation.
|
|
|
|