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GEMS FacultyA | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z Ackerman, StevenPh.D., McGill University Research Interests Research Description Transcriptional mechanisms regulating blood cell development and gene expression. Eosinophil effector functions in asthma and other allergic diseases, tissue remodeling and fibrosis.
Alexander, KennethPh.D., University of Washington Research Interests Research Description Use of behavioral and electrophysiological tests to define the relationship between vision impairment and the pathophysiology of ocular diseases.
Art, JonathanPh.D., University of Chicago Research Interests Research Description Biophysical properties of Cochlear Hair Cells
Azar, DimitriM.D., American University of Beirut Research Interests Research Description Corneal wound healing and matrix metalloproteinase.
Bongarzone, Ernesto R.PhD, University of Buenos Aires Research Interests Research Description Molecular and cellular mechanisms controlling endogenous remyelination; improving myelin repair with stem cell transplantation
Bouvier, MarlenePh.D., McGill University Research Interests Research Description An area of our research is focused on studying the class I antigen presentation pathway. The cell-surface presentation of antigens by class I MHC molecules is the culmination of an elaborated process that takes place in the endoplasmic reticulum (ER) and involves proteins such as tapasin, calreticulin, ERp57, and the transported associated with antigen processing. The characterization of these proteins and their functions is essential for elucidating the mechanistic basis of antigen selection in the ER. Another area of our research is to study the molecular basis of viral immune evasion mechanisms that operate by interfering with the class I antigen presentation pathway.
Brady, ScottPh.D., University of Southern California Research Interests Research Description Molecular Mechanisms of Axonal Transport; Specialization of the Neuronal Cytoskeleton; Glial Modulation of Neuronal Function; and Effects of Physiological Stress on Neurons.
Brodie, MarkPh.D., University of Illinois at Chicago Research Interests Research Description Electrophysiology of dopamine neurons of the reward system of the central nervous system
Caffrey, MichaelPh.D., University of Arizona Research Interests Research Description Determinants of viral and toxin entry
Chakrabarty, AnandaPh.D, University of Calcutta Research Interests Research Description Microorganisms and cancer; interaction of microbial redox proteins with the tumor suppressor protein p53; development of anticancer drugs from microbial sources.
Chan, LawrenceM.D., University of Pennsylvania Research Interests Research Description Molecular Mechanism of Chronic Skin Inflammation, Atopic Dermatitis.
Chauhan, NeelimaPh.D., University of Baroda, India Research Interests Research Description Prevention of Alzheimer's pathogenesis
Chen, ZhengM.D., Ph.D., Peking Union Medical College Research Interests Research Description Fundamental immunology of antigen- specific gamma delta T cells; gamma delta T cell-based immunotherapeutics; MHC class I-restricted CD8+ CTL responses in TB and AIDS; Vaccine development for TB and AIDS; Immunopathogenesis in AIDS virus- mycobacterial coinfection; T cell- targeted biodefense.
Chishti, AtharPh.D., University of Melbourne, Australia Research Interests Research Description Assembly and Regulation of the Cytoskeleton. Function of MAGUKs (membrane associated guanylate kinases); role of calpains in platelet function; mechanisms of malaria parasite pathogenesis in red blood cells; cell proliferation and tumor suppression pathways.
Cohen, EdwardM.D., Washington University Research Interests Research Description DNA based vaccines for cancer therapy.
Colamonici, OscarM.D., University of Uruguay Research Interests Research Description Characterization of the structure of the interferon alpha receptor (IFN R) and cytokine signaling.
Colley, KarenPh.D., Washington University Research Interests Research Description Control of glycoprotein biosynthesis during development and disease; mechanisms of Golgi protein trafficking and localization.
Cook, JamesMD, Baylor University Research Interests Research Description Viral gene control of cellular response to injury Immunopathogenesis and drug discovery for Anthrax
de Lanerolle, PrimalPhD, University of California, San Diego Research Interests Research Description The cytoskeleton in signal transduction; Molecular motors in the nucleus
de Tombe, PieterPh.D. University of Calgary, Canada Research Interests Research Description Our research program is focused on unraveling molecular mechanisms underlying contractile protein function and regulation in health and disease. Our studies are both integrative and molecular in nature, spanning from control of cardiac pump function in the intact organism, to protein structure-function relationships as determined at the level of a few sarcomeres using sophisticated biophysical techniques. Our long term goals are to gain full understanding of the chemo-mechanical transduction processes underlying muscle contraction, and to use this knowledge to provide for a basic scientific rational to guide development of future novel treatment strategies aimed to combat cardiac disease in man.
De Vries, GeorgePh.D., University of Illinois at the Medical Center Research Interests Research Description Neuron-glial interactions in myelination and demyelination
Diekwisch, ThomasDDS, Ph.D. (sci), Ph.D. (phil), Philipps-University of Marburg, West Germany Research Interests Research Description Developmental, molecular, and evolutionary biology of tooth enamel and periodontium
Du, XiaopingM.D., Ph.D., University of Sydney, Australia Research Interests Research Description Thrombosis, hemostasis, and vascular biology; molecular mechanisms and molecular pharmacology of platelet and endothelial cell functions.
Erdös, ErvinM.D., University of Munich Research Interests Research Description Enzymology of peptide metabolism and its inhibitors; modes of action of the therapeutically widely used angiotensin-I converting enzyme inhibitors at cellular and subcellular levels.
Fall, ChrisPh.D., University of Virginia Research Interests Research Description Computational and experimental approaches for understanding the neuromodulation of cortical activity patterns; computational and experimental cell biology of intracellular Ca2+ signaling and related second messengers; mechanisms of cell death in neurodegenerative disease.
Federle, MichaelPh.D., Emory University Research Interests Research Description Cell-cell signaling in bacteria, a process termed Quorum Sensing. We are identifying the chemical signals and signaling pathways used by bacteria to control population-wide behaviors, which include their ability to cause disease in humans. Eventually we hope to discover means by which we can interfere with bacteria's communication processes and ultimately alter the progression of bacterial infections.
Feinstein, DouglasPh.D., John Hopkins University Research Interests Research Description Molecular analysis of NOS2 expression and regulation by noradrenaline, PPAR agonists
Freitag, NancyPhD, University of California at Los Angeles Research Interests Research Description
Frolov, MaximPh.D, Moscow State University Research Interests Research Description Mechanisms of regulation of eukaryotic gene expression and the role of chromatin. The function of E2F/RB repressor complexes in Drosophila.
Fukai, TohruMD, PhD, Kyushu University, Fukuoka, Japan Research Interests Research Description To determine the role of oxidative stress and copper transport system in cardiovascular disease.
García-Martínez, JesúsM.D., Ph.D., CINVESTAV, México Research Interests Research Description Signal transduction in striated muscle. Excitation-contraction coupling and gene expression in skeletal and cardiac muscle.
Gartel, AndreiPh.D., Institute of Virology, Moscow, Russia Research Interests Research Description Regulation of CDK inhibitor p21 in normal and cancer cells, Anticancer drugs that target antiapoptotic pathways
Gettins, PeterD. Phil., Oxford University Research Interests Research Description Structure and function of serpin superfamily; ligand recognition by receptors of the LDL receptor family; protein NMR spectroscopy; X-ray crystallography
Gibori, GeulaPhD, Tel Aviv University Research Interests Research Description
Goldspink, PaulPh.D., University of Illinois at Chicago Research Interests Research Description Molecular aspects of cardiac disease and injury. Growth and repair mechanisms through local growth factor regulation, in particular IGF-1.
Hales, Dale BuchananPhD, University Colorado Health Science Center Research Interests Research Description The goal of our work is to gain an understanding the role of oxidative stress in the etiology of diseases of the reproductive system including prostate and ovarian cancer, hypogonadism associated with aging (andropause) and diabetes. Our studies are centered on mitochondrial biology. We have a long standing interest steroid hormone biochemistry-- steroidogenesis and steroid action. The unifying theme of the work is immune-endocrine and environmental control of male reproductive health, in particular how the immune system and the environment affect Leydig cell function.
Hay, NissimPhD, Weizmann Institute, Israel Research Interests Research Description Analyses of apoptosis, cell cycle control, metabolism, and life span mediated by growth factors, at the cellular and organismal levels.
He, BinPhD, Purdue University Research Interests Research Description Biology and pathogenesis of virus infection; virus-host interactions; virus strategies to escape host response
Hecht, GailMD, Loyola University Research Interests Research Description Mechanisms of effects of enteropathogenic and enterohemorrhagic E. coli on host intestinal epithelial cell functions including tight junction permeability, the inflammatory response, and ion transport.
Hudson, RandallPh.D., Washington State University Research Interests Research Description
Ikegaki, NaohikoPhD, University of Pennsylvania Research Interests Research Description Biology and therapeutic approaches of neuroblastoma; functions of MYCN, EPH receptors, and ephrims in neuroblastoma
Jaffe, RandalPhD, University of California at Davis Research Interests Research Description Mechanism of hormonal regulation of female reproductive genes.
Kalyanasundaram, RamaswamyPhD, University of Calgary Research Interests Research Description Molecular basis of host evasion by pathogens; identify novel antigens for vaccine or drug development
Kanteti, PrasadPhD, Poona University, India Research Interests Research Description Apoptosis mechanisms and cancer, understanding the nature of host response to viral infection.
Kaplan, JackPhD, London University Research Interests Research Description Molecular characterization of P-type ATPases (Ion Pumps): structure- function relations, synthesis, assembly and trafficking. Mechanisms and Regulation of Copper transport in Human Cells.
Katzen, AlisaPhD, University of California, San Francisco Research Interests Research Description Molecular and genetic analysis of the coordination of cell cycle regulation and differentiation during development; functional role of a proto-oncogene.
Kennedy, JohnPhD, Medical College of Virginia Research Interests Research Description Molecular Mechanisms controlling expression of metabolic genes during cardiac and skeletal muscle adaptation.
Kenney, LindaPhD, University of Pennsylvania Research Interests Research Description Two-component signal transduction; Regulation of Salmonella pathogenicity Island 2 gene expression; Regulation of outer membrane proteins by EnvZ/OmpR
Kenter, AmyPhD, Yeshiva (Albert Einstein College of Medicine) Research Interests Research Description Genetic mechanisms of immunoglobulin gene recombination; DNA-binding proteins; B cell specific nucleic enzymes; plasmid recombination assays.
Kozasa, TohruMD/PhD, University of Tokyo, Japan Research Interests Research Description G-protein-mediated signal transduction pathways; Function of RGS proteins. Mechanism of regulation of Rho family GTPases (Rho, Rac, Cdc42) by G protein- coupled receptors.
LaDu, Mary JoPhD, University of Illinois at Chicago Research Interests Research Description Identify the role of apoE:A-Beta complexes and apoE receptors in A- beta ?induced neurotoxicity
Lam, StephenPhD, University of Toronto Research Interests Research Description Platelet adhesive functions in hemostasis and thrombosis; structure- function relationship of integrin alpha IIb?3.
Lau, LesterPh.D., Cornell University Research Interests Research Description Tumor Angiogenesis, Cardiovascular Development, Extracellular Matrix Signaling, Aging
Lavie, ArnonPh.D., Brandeis University Research Interests Research Description Structure-based design of novel therapeutic agents by prodrug development and enzyme modifications. X-ray crystallographic structure determination of enzymes involved in prodrug activation.
Lazarov, OrlyPh.D., Weizmann Institute of Science Research Interests Research Description Cellular and molecular mechanisms underlying Alzheimer's disease; Misregulation of neurogenic processes in the AD brain; Neurogenesis and stem cell-based therapeutic approaches.
Le Breton, GuyPh.D., University of Chicago Research Interests Research Description Fundamental mechanisms and signal transduction processes involved in platelet activation and inhibition.
Lewandowski, E. DouglasPh.D., University of Texas Southwestern Medical School Research Interests Research Description Research explores the metabolic basis of cardiac dysfunction in heart disease. Focus is on metabolic flux regulation via enzyme expression using a novel combination of molecular techniques and magnetic resonance spectroscopy of the intact heart. Gene therapy, through the in vivo delivery of cardiac-specific, adenoviral constructs, enables the manipulation of enzyme expression and activity in animal models of heart disease. The program develops new methods for nuclear magnetic resonance (NMR) to detect intracellular transport rates and chemical reactions in intact, functioning tissues using new approaches for stable isotope kinetics in whole organs.
Li, JianxunPh.D., City University of New York Research Interests Research Description Molecular Mechanism of Immune Cell Activation.
Li, QingboPh.D., Iowa State University Research Interests Research Description My laboratory is interested in the role and the pathway of anaerobic respiration by M. tuberculosis for intracellular growth and persistence. Using proteomics approach, we are trying to identify and characterize the genes specific for the microaerobic or anaerobic metabolism of M. tuberculosis. We use metabolic labeling methods to quantify the details of protein synthesis by M. tuberculosis grown within macrophages. We are also involved in elucidating the T cell antigens synthesized by intracellular mycobacteria. This knowledge is being used for understanding the mechanism of tuberculosis latency.
Lipton, HowardM.D., University of Nebraska Research Interests Research Description Mechanisms of viral persistence and immunopathogenesis of the picornavirus, Theiler's virus, in the central nervous system of mice
Little, DeborahPh.D., Brandeis University Research Interests Research Description Ageing, dementia and neuroimaging
Lysakowski, AnnaPh.D., University of Illinois at Chicago Research Interests Research Description Ionic composition and synaptic innervation of hair cells. Efferent innervation of the vestibular periphery
Malik, A.B.Ph.D., University of Toronto, Canada Research Interests Research Description Gene regulation in endothelial cells; expression of adhesion molecules and their transcriptional regulation; regulation of endothelial transport; assembly of adherens junctions; function of caveolin-1 in endothelial cells.
Marucha, PhillipPhD, University of Connecticut Research Interests Research Description Stress-Impaired Oxygen Dependent Transcription in Wounds; Distress, Saliva Composition, and Saliva Functions; Interdisciplinary Research in Cancer from an Oral Perspective; Modulation of Inflammation by Stress and Social Factors; Mechanisms of Neuroendocrine Regulation of Wound Healing During Aging
Matsumura, PhilipPh.D., Rochester University Research Interests Research Description Mechanisms of signal transduction in bacterial chemotaxis. By combining genetics with biochemistry and structural chemistry, we are defining the detailed protein-protein interactions that constitute the biochemical pathway of signal transduction.
McLachlan, AlanPh.D., University of Aberdeen, Scotland Research Interests Research Description Regulation of hepatitis B virus transcription and replication
Mehta, DollyPh.D., Delhi University, India Research Interests Research Description Rho regulation of actin polymerization.
Merrill, BradPh.D., University of California, San Diego Research Interests Research Description Mammalian embryogenesis; Stem Cell Biology; WNT signaling and Tcf/Lef mediated control of cell fate decisions
Minshall, RichardPh.D., University of Illinois at Chicago Research Interests Research Description Investigates signaling mechanisms regulating paracellular and transcellular permeability of the endothelium to macromolecules and therapeutic agents. Confocal microscopy, physiological, molecular, cellular, and biochemical approaches are used to study trafficking of caveolae, organization and remodeling of the cytoskeleton and cell-cell junctions, protein and fluid permeability, and signaling modules that regulate endothelial cell function. Current projects focus on 1) the signaling molecules that regulate caveolae-mediated endocytosis and transcytosis, 2) delivery of therapeutic agents across the vascular barrier, and 3) the role of caveolae in inflammation-induced increase in permeability.
Mirkin, SergeiPh.D., Institute of Molecular Genetics, Russian Academy of Sciences Research Interests Research Description Genome Structure and Functioning; Molecular Mechanisms of Genetic Processes; Structure and Stability of DNA
Mokyr, MargalitPh.D., Rush University Research Interests Research Description Molecular mechanism of immunopotentiation by anticancer drugs
Nakajima, YasukoM.D., Ph.D., University of Tokyo Research Interests Research Description Signal transduction of ion channel modulation
Nakajima, ShigehiroM.D., Ph.D., University of Tokyo, Japan Research Interests Research Description Electrophysiological and molecular biological investigations on ion channels in brain neurons with emphasis on signal transduction mechanisms.
Nakamura, ToruPh.D, University of Colorado, Boulder Research Interests Research Description Roles of Checkpoint Proteins and Chromatin Modifications in Genome Stability, DNA repair and Telomere Maintenance
Nonn, LarisaPhD, University of Arizona Research Interests Research Description Prostate cancer prevention by dietary agents (vitamin D, soy, lycopene) Primary human prostatic cell cultures as a model system The role of microRNAs and prostate cancer prevention. mRNA and microRNA expression profiling from archival tissue specimens
O'Bryan, John P.Ph.D., University of North Carolina at Chapel Hill Research Interests Research Description The research in the lab is focused on the role of scaffolding proteins in the regulation of signal transduction pathways, protein ubiquitylation, trafficking and endocytosis.
Otte, StefanPh.D., University of Goettingen, Germany Research Interests Research Description Mechanisms underlying ER to Golgi Transport. Organization of the secretory pathway.
Pandey, SubhashPh.D., Central Drug Research Institute Research Interests Research Description Molecular and cellular neurobiology of alcohol and drug addiction.
Pepperberg, David R.Ph.D. Research Interests Research Description Development of nanoscale neuromodulating platforms as a therapy for retinal degenerative diseases. Retinal electryphysiology and biochemistry.
Popov, SergeyPh.D., Moscow State University Research Interests Research Description
Prabhakar, BellurPh.D., Johns Hopkins University Research Interests Research Description Role of regulatory T cells in autoimmunity, Molecular mechanisms of actions of IG20 splice variants that can promote either apoptosis or cell- growth. Therapeutic interventions against SARS.
Qian, HaohuaPh.D. Research Interests Research Description Cellular and molecular basis of signal processing in the retina.
Qu, TingyuM.D., Ph.D., Kobe university School of Medicine, Japan Research Interests Research Description Therapeutic potential of human stem cells in neurodegenerative diseases
Radulovacki, MiodragM.D., Ph.D., University of Belgrade Medical School, Belgrade, Yugoslavia. Research Interests Research Description Pharmacology of sleep and sleep apnea.
Rao, MrinaliniPh.D., University of Michigan Research Description Cellular and molecular basis of regulating salt and water transport across epithelia
Rasenick, MarkPh.D., Wesleyan University Research Interests Research Description G protein signaling and the cytoskeleton; regulation of synaptic shape by neurostranmitters; molecular biology of depression
Raychaudhuri, PradipPh.D., Albert Einstein College of Medicine Research Interests Research Description We use both mammalian and yeast genetics to study DNA damage response, cell cycle checkpoints and tumor suppression
Rong, LijunPh.D., Purdue University Research Interests Research Description Entry mechanisms of emerging viruses such as Ebola and SARS
Russell, BrendaPhD, University London, UK Research Interests Research Description Dr. Russell's scientific training, background, experience, and productivity encompass a range of disciplines and forge linkages in the continuum between quantitative biology, bioengineering and physiology. Her current NIH support funds two collaborative projects, one on heart failure for regulation of protein synthesis and remodeling of cell shape, and the other on development of a novel cell culture system using bioengineering and surface chemistry modification. Many of her studies have been done in close collaboration with clinicians (muscular dystrophies, urinary incontinence, heart failure).
Shahidi, MahnazPh.D. Research Interests Research Description Development of optical imaging systems for quantitative assesment of eye diseases.
Shukla, DeepakPh.D., University of Illinois at Chicago Research Interests Research Description Molecular basis for viral entry; mouse model for ocular herpes
Skidgel, RandalPh.D., University of California, San Diego Research Interests Research Description Role of human carboxypeptidases in activation or inactivation of peptide hormones and regulation of nitric oxide production.
Snapp, KarenD.D.S., Ph.D., University of Iowa Research Interests Research Description Leukocyte adhesion and migration; interactions mediated by the selectin family of adhesion molecules.
Solaro, R. JohnPh.D., University of Pittsburgh Research Interests Research Description Integrated Molecular, Structural, and Cellular Biology of Heart Muscle Physiology, Pathology, and Pharmacology
Tang, Xao X.PhD, University of Pennsylvania Research Interests Research Description Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma
Tao, LinD.D.S., Ph.D., University of Connecticut Research Interests Research Description Microbial genetics of streptococci and lactobacilli
Tiruppathi, ChinnaswamyPh.D., University of Madras Research Interests Research Description Our primary research interest is to study the molecular mechanism that regulates vascular inflammation. Pro- inflammatory mediator thrombin induces vascular inflammation by cleaving the endothelial cell surface protease activated receptor-1 (PAR-1). PAR-1 activation causes vascular leakage and neutrophil adhesion-mediated vascular injury. Ca2+ signaling plays an important role in the mechanism of thrombin-induced vascular injury. Currently, we are investigating how thrombin increases intracellular Ca2+ by opening plasma membrane transient receptor potential channels expressed in endothelial cells. In addition, we are also investigating the role of Ca2+ signaling in the mechanism of nuclear factor ?B (NF-?B) activation- dependent expression of inflammatory genes in endothelial cells.
Tyner, AngelaPh.D. University of Chicago Research Interests Research Description Regulation of epithelial cell differentiation; Cell cycle regulation in regenerating tissues; Cancer
Ucker, DavidPh.D., University of California, San Francisco Research Interests Research Description Mechanism and regulation of the processes of physiological cell death and the innate immune recognition and non-inflammatory clearance of cell corpses.
Uprichard, SusanPhD, Harvard University Research Interests Research Description
Ushio-Fukai, MasukoPhD, Kyushu University, Fukuoka, Japan Research Interests Research Description To determine the role of reactive oxygen species in angiogenesis and cardiovascular diseases using cell culture, live cell imaging, cell fractionation, molecular and cell biological analysis as well as in vivo models with knockout and transgenic mice.
Volz, KarlPh.D., University of California, San Diego Research Interests Research Description Protein structure and function
Voyno-Yasenetskaya, TatyanaM.D., Ph.D., Institute of Pathophysiology, Moscow Research Interests Research Description G-protein regulatory mechanisms and control of cellular proliferation and cytoskeleton.
Walden, WilliamPh.D., Washington University Research Interests Research Description Mechanisms of iron regulation and FeS cluster assembly; translational mechanisms and regulation.
Wary, Kishore K.PhD, North Eastern Hill University, India Research Interests Research Description Biology of endothelial cells; cell- cell and cell-matrix interactions in endothelial cells; integrin, beta- catenin, VE-cadherin and Wnt mediated signaling in endothelial cells; adult stem cells; wound healing; angiogenesis and tumor progression.
Wolf, WilliamPh.D., George Washington University Research Interests Research Description Neurochemical and behavioral analysis of neural plasticity related to neurological/psychiatric disorders and their treatment
Wolska, BeataPh.D., Postgraduate Center of Medical Education, Warsaw, Poland Research Interests Research Description Role of calcium and myofilaments in controlling cardiac function.
Wright, Margaret E.Ph.D., Yale University Research Interests Research Description I combine population-based (epidemiologic) and laboratory approaches to study the effects of dietary and other lifestyle factors on the etiology of prostate and lung cancers. I also examine how genetic susceptibility modifies associations between these factors and cancer risk.
Ye, RichardM.D., Ph.D., Washington University Research Interests Research Description Signaling through G-protein-coupled receptors; molecular mechanisms of leukocyte activation.
Yue, BeatricePh.D. Research Interests Research Description Biochemical and molecular basis of keratoconus; studies of glaucoma genes.
Zhao, You-YangPhD Research Interests
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